There are things that neutralize folic acid, most notably some medications. Some medications can affect the way folic acid works, and folic acid can also affect the effectiveness of certain medications that are used to treat certain health conditions. Folic acid should not be used within two hours before or after taking indigestion medicines, as these medicines stop folic acid from being absorbed into the body.

Also, tell your doctor if you are taking any of the following medicines before using folic acid:

You should also tell your doctor before mixing folic acid with herbal remedies or supplements, as some types of vitamins and mineral supplements already contain a percentage of folic acid, so be careful not to take a larger dose of folic acid than the body needs.